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BlogController :: show

Request

GET Parameters

No GET parameters

POST Parameters

No POST parameters

Uploaded Files

No files were uploaded

Request Attributes

Key	Value
_controller	"App\Controller\BlogController::show"
_firewall_context	"security.firewall.map.context.main"
_locale	"de"
_redirected	true
_route	"blog.show.de"
_route_params	[`"_locale" => "de" "slug" => "menopause-oestradiol-atrophie-et-cremes-vaginales"`]
_security_firewall_run	"_security_main"
_stopwatch_token	"803389"
articleTranslate	App\Entity\BlogArticleTranslation {#502-id: 2 -titre: "Ménopause : crèmes vaginales à base d’oestradiol pendant 4 semaines." -contenu: """ <p>Au moment de la ménaupose,  la sécrétion d’oestradiol par les ovaires chute drastiquement. C'est pourquoi pour traiter la ménopause il existe différents traitements. L'un d'entre eux est une créme vaginale. Ca durée d’utilisation est limitée à 4 semaines pour les crèmes vaginales à base d’oestradiol les plus fortement dosées.</p>\r\n \r\n <p>Crèmes vaginales</p>\r\n \r\n <p>Pour commencer, il est important de limiter l'utilsation des crèmes. C'est ce que le comité d'évaluation des risques de pharmacovigilance (PRAC) de l'Agence européenne des médicaments (EMA) recommande. Elles sont effectivement puissamment dosées. Elles contiennent de l'&oelig;stradiol à 100 μg/g (0,01%) à une unique période de traitement ne dépassant pas 4 semaines chez les femmes ménopausées.</p>\r\n \r\n <p>C'est pourquoi, cette mesure a pour objectif de réduire le risque d'effets indésirables. Cela peut donc provoquer la formation de caillots sanguins, la survenue d’accidents vasculaires cérébraux et certains types de cancer. Tout ceci pouvant résulter de l'absorption sanguine d'estradiol de crèmes intravaginales utilisées pour soulager les symptômes de l'atrophie vaginale chez les femmes ménopausées.</p>\r\n \r\n <h3>Taux d'oestradiol trop elevé</h3>\r\n \r\n <p>La PRAC a revu toutes les données d’efficacité et de sécurité concernant ces crèmes. Il est apparu que, chez les femmes ménopausées qui utilise ces crèmes, « les taux d'estradiol dans le sang est supérieurs aux taux normaux après la ménopause (jusqu’à 5 fois supérieurs aux seuils de référence de 10–20 pg/ml) ».</p>\r\n \r\n <p><a href="https://cabinet-medical.eu/menopause-oestradiol-atrophie-et-cremes-vaginales/"><img alt="" class="" src="https://cabinet-medical.eu/wp-content/uploads/2019/10/menopauseprecoce1-300x150.jpeg" style="height:254.965px; width:495.998px" /></a></p>\r\n \r\n <p>Les recommandations de prescription vont donc être mises à jour en ce qui concerne ces crèmes à base d'estradiol. Elles comprendront notamment un message d’avertissement. En indiquant qu'elles ne doivent être utilisées que pendant une seule période de traitement ne dépassant pas 4 semaines. Cet avertissement va figurer sur les emballages extérieur et intérieur. Également la taille du tube ne dépassera pas 25 g pour éviter une utilisation plus prolongée que celle recommandée.</p>\r\n \r\n <p>Par ailleurs, ces crèmes fortement dosées ne doivent pas être prescrites en sus d’un traitement hormonal de la ménopause.</p>\r\n \r\n <p>Réexamen de ces médicaments</p>\r\n \r\n <p>La révision, démarrée en avril 2019, a été entreprise à la demande de la Commission européenne, suite d'un arrêt de la Cour de justice de l'Union européenne. Cet arrêt « annulait en partie les conclusions d'un précédent réexamen de ces médicaments effectué par le PRAC en 2014 pour des raisons de procédure ».</p>\r\n \r\n <p>Si la Cour de justice n’a pas remis en cause les conclusions scientifiques [du PRAC]. L’annulation partielle a toutefois invalidé certaines des mesures mises en &oelig;uvre pour réduire le risque.</p>\r\n \r\n <p>Ces topiques sont déjà autorisés au niveau national. C'est pourquoi ces recommandations vont être envoyées au Groupe de Coordination de Reconnaissance Mutuelle et des Procédures Décentralisées pour l’Humain (CMDh). Ils vont prendre la décision de leur implémentation dans chacun des pays membres. Cet organisme est responsable de l’harmonisation des standards de sécurité pour les médicaments. Savoir si ils sont autorisés au travers de procédures nationales dans l’Union Européenne, en Islande, au Lichtenstein et en Norvège.</p>\r\n \r\n <p>source : medscape</p> """ -slug: "menopause-oestradiol-atrophie-et-cremes-vaginales" #locale: "fr" #translatable: Proxies\__CG__\App\Entity\BlogArticle {#546 …}}
slug	"menopause-oestradiol-atrophie-et-cremes-vaginales"

Request Headers

Header	Value
accept	"/"
accept-encoding	"gzip, br, zstd, deflate"
cookie	"sf_redirect=%7B%22token%22%3A%22881ff3%22%2C%22route%22%3A%22switcher%22%2C%22method%22%3A%22GET%22%2C%22controller%22%3A%7B%22class%22%3A%22App%5C%5CController%5C%5CFrontController%22%2C%22method%22%3A%22switcher%22%2C%22file%22%3A%22%5C%2Fvar%5C%2Fwww%5C%2Fclients%5C%2Fclient1%5C%2Fweb17%5C%2Fweb%5C%2Fsrc%5C%2FController%5C%2FFrontController.php%22%2C%22line%22%3A63%7D%2C%22status_code%22%3A302%2C%22status_text%22%3A%22Found%22%7D; PHPSESSID=ba8gvbgs22iofmdtatuoechul2"
host	"dr.espai-web.com"
referer	"https://dr.espai-web.com/de/switcher/blog.show?params%5Bslug%5D=menopause-oestradiol-atrophie-et-cremes-vaginales"
user-agent	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
x-php-ob-level	"1"

Request Content

Request content not available (it was retrieved as a resource).

Response

Response Headers

Header	Value
cache-control	"no-cache, private"
content-type	"text/html; charset=UTF-8"
date	"Tue, 29 Apr 2025 18:26:00 GMT"
x-debug-token	"da070c"

Cookies

Request Cookies

Key	Value
PHPSESSID	"ba8gvbgs22iofmdtatuoechul2"
sf_redirect	"{"token":"881ff3","route":"switcher","method":"GET","controller":{"class":"App\\Controller\\FrontController","method":"switcher","file":"\/var\/www\/clients\/client1\/web17\/web\/src\/Controller\/FrontController.php","line":63},"status_code":302,"status_text":"Found"}"

Key

Value

PHPSESSID

"ba8gvbgs22iofmdtatuoechul2"

sf_redirect

"{"token":"881ff3","route":"switcher","method":"GET","controller":{"class":"App\\Controller\\FrontController","method":"switcher","file":"\/var\/www\/clients\/client1\/web17\/web\/src\/Controller\/FrontController.php","line":63},"status_code":302,"status_text":"Found"}"

Response Cookies

No response cookies

Session 1

Session Metadata

Key	Value
Created	"Tue, 29 Apr 25 20:25:45 +0200"
Last used	"Tue, 29 Apr 25 20:25:59 +0200"
Lifetime	0

Session Attributes

Attribute	Value
_csrf/https-contact	"lhKCOIGhmKSWVJpkRlu0TXoppXIcABmhLCN90-sv39Y"

Session Usage

1 Usages

Stateless check enabled

Usage
Symfony\Component\Security\Http\Firewall\ContextListener:174 Show trace [[ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/security-http/Firewall/ContextListener.php" "line" => 174 "function" => "remove" "class" => "Symfony\Component\HttpFoundation\Session\Session" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/Debug/WrappedListener.php" "line" => 115 "function" => "onKernelResponse" "class" => "Symfony\Component\Security\Http\Firewall\ContextListener" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/EventDispatcher.php" "line" => 230 "function" => "__invoke" "class" => "Symfony\Component\EventDispatcher\Debug\WrappedListener" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/EventDispatcher.php" "line" => 59 "function" => "callListeners" "class" => "Symfony\Component\EventDispatcher\EventDispatcher" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php" "line" => 153 "function" => "dispatch" "class" => "Symfony\Component\EventDispatcher\EventDispatcher" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php" "line" => 196 "function" => "dispatch" "class" => "Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php" "line" => 184 "function" => "filterResponse" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php" "line" => 75 "function" => "handleRaw" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/Kernel.php" "line" => 202 "function" => "handle" "class" => "Symfony\Component\HttpKernel\HttpKernel" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php" "line" => 35 "function" => "handle" "class" => "Symfony\Component\HttpKernel\Kernel" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/vendor/autoload_runtime.php" "line" => 29 "function" => "run" "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner" "type" => "->" ] [ "file" => "/var/www/clients/client1/web17/web/public/index.php" "line" => 5 "args" => [ "/var/www/clients/client1/web17/web/vendor/autoload_runtime.php" ] "function" => "require_once" ]]

Usage

Symfony\Component\Security\Http\Firewall\ContextListener:174

Show trace

[
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/security-http/Firewall/ContextListener.php"
    "line" => 174
    "function" => "remove"
    "class" => "Symfony\Component\HttpFoundation\Session\Session"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/Debug/WrappedListener.php"
    "line" => 115
    "function" => "onKernelResponse"
    "class" => "Symfony\Component\Security\Http\Firewall\ContextListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 230
    "function" => "__invoke"
    "class" => "Symfony\Component\EventDispatcher\Debug\WrappedListener"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/EventDispatcher.php"
    "line" => 59
    "function" => "callListeners"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/event-dispatcher/Debug/TraceableEventDispatcher.php"
    "line" => 153
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\EventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 196
    "function" => "dispatch"
    "class" => "Symfony\Component\EventDispatcher\Debug\TraceableEventDispatcher"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 184
    "function" => "filterResponse"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/HttpKernel.php"
    "line" => 75
    "function" => "handleRaw"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/http-kernel/Kernel.php"
    "line" => 202
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\HttpKernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/symfony/runtime/Runner/Symfony/HttpKernelRunner.php"
    "line" => 35
    "function" => "handle"
    "class" => "Symfony\Component\HttpKernel\Kernel"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/vendor/autoload_runtime.php"
    "line" => 29
    "function" => "run"
    "class" => "Symfony\Component\Runtime\Runner\Symfony\HttpKernelRunner"
    "type" => "->"
  ]
  [
    "file" => "/var/www/clients/client1/web17/web/public/index.php"
    "line" => 5
    "args" => [
      "/var/www/clients/client1/web17/web/vendor/autoload_runtime.php"
    ]
    "function" => "require_once"
  ]
]

Flashes

No flash messages were created.

Server Parameters

Defined in .env

Key	Value
APP_ENV	"dev"
APP_SECRET	"ac448c844e6feac31d85719588b07267"
DATABASE_URL	"mysql://c1dr:PtfpY3_PvZwP5@localhost:3306/c1dr"
GOOGLE_RECAPTCHA_SECRET_KEY	"6LcSSRAqAAAAAM1CP03JlAcuGrmoby6UprIK5uIv"
GOOGLE_RECAPTCHA_SITE_KEY	"6LcSSRAqAAAAAKciffJHFqJGHEUXCEVm5NiZqjcz"
LOCK_DSN	"flock"
MAILER_DSN	"smtp://suivi@espai-web.com:DQt68m_vYaLx@ns3013758.ip-149-202-75.eu:587"
MESSENGER_TRANSPORT_DSN	"doctrine://default"

Defined as regular env variables

Key	Value
APP_DEBUG	"1"
CONTEXT_DOCUMENT_ROOT	"/var/www/clients/client1/web17/web"
CONTEXT_PREFIX	""
DOCUMENT_ROOT	"/var/www/clients/client1/web17/web"
FCGI_ROLE	"RESPONDER"
GATEWAY_INTERFACE	"CGI/1.1"
H2PUSH	"off"
H2_PUSH	"off"
H2_PUSHED	""
H2_PUSHED_ON	""
H2_STREAM_ID	"65"
H2_STREAM_TAG	"791882-2454-65"
HOME	"/var/www/clients/client1/web17"
HOSTNAME	""
HTTP2	"on"
HTTPS	"on"
HTTP_ACCEPT	"/"
HTTP_ACCEPT_ENCODING	"gzip, br, zstd, deflate"
HTTP_COOKIE	"sf_redirect=%7B%22token%22%3A%22881ff3%22%2C%22route%22%3A%22switcher%22%2C%22method%22%3A%22GET%22%2C%22controller%22%3A%7B%22class%22%3A%22App%5C%5CController%5C%5CFrontController%22%2C%22method%22%3A%22switcher%22%2C%22file%22%3A%22%5C%2Fvar%5C%2Fwww%5C%2Fclients%5C%2Fclient1%5C%2Fweb17%5C%2Fweb%5C%2Fsrc%5C%2FController%5C%2FFrontController.php%22%2C%22line%22%3A63%7D%2C%22status_code%22%3A302%2C%22status_text%22%3A%22Found%22%7D; PHPSESSID=ba8gvbgs22iofmdtatuoechul2"
HTTP_HOST	"dr.espai-web.com"
HTTP_REFERER	"https://dr.espai-web.com/de/switcher/blog.show?params%5Bslug%5D=menopause-oestradiol-atrophie-et-cremes-vaginales"
HTTP_USER_AGENT	"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
PATH	"/usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin"
PHP_SELF	"/public/index.php"
QUERY_STRING	""
REDIRECT_H2PUSH	"off"
REDIRECT_H2_PUSH	"off"
REDIRECT_H2_PUSHED	""
REDIRECT_H2_PUSHED_ON	""
REDIRECT_H2_STREAM_ID	"65"
REDIRECT_H2_STREAM_TAG	"791882-2454-65"
REDIRECT_HTTP2	"on"
REDIRECT_HTTPS	"on"
REDIRECT_REDIRECT_H2PUSH	"off"
REDIRECT_REDIRECT_H2_PUSH	"off"
REDIRECT_REDIRECT_H2_PUSHED	""
REDIRECT_REDIRECT_H2_PUSHED_ON	""
REDIRECT_REDIRECT_H2_STREAM_ID	"65"
REDIRECT_REDIRECT_H2_STREAM_TAG	"791882-2454-65"
REDIRECT_REDIRECT_HTTP2	"on"
REDIRECT_REDIRECT_HTTPS	"on"
REDIRECT_REDIRECT_SSL_TLS_SNI	"dr.espai-web.com"
REDIRECT_REDIRECT_STATUS	"200"
REDIRECT_SSL_TLS_SNI	"dr.espai-web.com"
REDIRECT_STATUS	"200"
REDIRECT_URL	"/public/de/blog/menopause-oestradiol-atrophie-et-cremes-vaginales"
REMOTE_ADDR	"3.141.193.189"
REMOTE_PORT	"8577"
REQUEST_METHOD	"GET"
REQUEST_SCHEME	"https"
REQUEST_TIME	1745951160
REQUEST_TIME_FLOAT	1745951160.0518
REQUEST_URI	"/de/blog/menopause-oestradiol-atrophie-et-cremes-vaginales"
SCRIPT_FILENAME	"/var/www/clients/client1/web17/web/public/index.php"
SCRIPT_NAME	"/public/index.php"
SERVER_ADDR	"149.202.75.231"
SERVER_ADMIN	"webmaster@dr.espai-web.com"
SERVER_NAME	"dr.espai-web.com"
SERVER_PORT	"443"
SERVER_PROTOCOL	"HTTP/2.0"
SERVER_SIGNATURE	""
SERVER_SOFTWARE	"Apache"
SSL_TLS_SNI	"dr.espai-web.com"
SYMFONY_DOTENV_VARS	"APP_ENV,APP_SECRET,MESSENGER_TRANSPORT_DSN,DATABASE_URL,MAILER_DSN,LOCK_DSN,GOOGLE_RECAPTCHA_SITE_KEY,GOOGLE_RECAPTCHA_SECRET_KEY"
TEMP	"/var/www/clients/client1/web17/tmp"
TMP	"/var/www/clients/client1/web17/tmp"
TMPDIR	"/var/www/clients/client1/web17/tmp"
USER	"web17"
proxy-nokeepalive	"1"

Sub Requests 3

BlogController :: lastArticles (token = 630273)

Key	Value
_controller	"App\Controller\BlogController::lastArticles"
_format	"html"
_locale	"de"
_stopwatch_token	"fa006d"

BlogController :: categories (token = 300d6a)

Key	Value
_controller	"App\Controller\BlogController::categories"
_format	"html"
_locale	"de"
_stopwatch_token	"3b5a6e"

FooterController :: showAction (token = eb0d1a)

Key	Value
_controller	"App\Controller\FooterController::showAction"
_format	"html"
_locale	"de"
_stopwatch_token	"b0dd5b"

Symfony Profiler

https://dr.espai-web.com/de/blog/menopause-oestradiol-atrophie-et-cremes-vaginales

Configuration Settings

Theme

Page Width

BlogController :: show

Request

GET Parameters

POST Parameters

Uploaded Files

Request Attributes

Request Headers

Request Content

Response

Response Headers

Cookies

Request Cookies

Response Cookies

Session 1

Session Metadata

Session Attributes

Session Usage

Flashes

Flashes

Server Parameters

Server Parameters

Defined in .env

Defined as regular env variables

Sub Requests 3

BlogController :: lastArticles (token = 630273)

BlogController :: categories (token = 300d6a)

FooterController :: showAction (token = eb0d1a)